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Product name	NMN ZERO REAL
Internal volume	90 capsules (for 30 days)
Name	Lactic acid bacteria (sterilized) powder contains processed food
Manufacturer's suggested retail price	29,700 JPY（include tax）
Raw material name	Lactic acid bacteria powder (sterilized lactic acid bacteria, dextrin), domestically produced β-nicotinamide mononucleotide, indigestible dextrin, black ginger extract powder, (black ginger extract, dextrin), crystalline cellulose cyclodextrin, HPC/calcium stearate, fine granule dioxide Silicon/shellac carnow halo

Nutritional information (3 tablets 900mg)
Energy	3.38kcal
Protein	0.21g
Lipid	0.04g
Carbohydrates	0.55g
Equivalent amount of salt	0.004g

Thoughts behind the development of NMN ZERO REAL.

Supplements (nutritional supplements) are foods that supplement nutrients that tend to be lacking in daily life.

β-NMN, which is expected to be a rejuvenating ingredient and was approved for production as a food product from a pharmaceutical product in 2020, is a component of the vitamin group originally produced by lactic acid bacteria in the human small intestine.

The same β-NMN produced in the human body is 100% pure β-NMN with few impurities, which is produced by yeast fermentation, but it is very expensive.

By supplementing β-NMN, which is produced in the body as we age, we can maintain youth and health, but the recommended amount of β-NMN required for adults per day is 150 mg to 300 mg. I am.

What the Rejuvenation System emphasizes is not only the safety of its ingredients, but also ``replenishing the power that it can no longer produce.'' In other words, it is important to make β- The purpose is to train the ability to create NMN, absorb it, and convert it into NAD+, which activates sirtuin, which is the key to rejuvenation.

The process by which NMN acts on rejuvenation

Step 1

The role of nano-type lactic acid bacteria in regulating the intestinal environment

Nano-type lactic acid bacteria are lactic acid bacteria whose particles have a diameter of less than 1 μm (micron) through nano-processing.

Since it is nano-sized, it is easily absorbed through the Peyer's patches in the small intestine, and has an effect on intestinal immunity and regular intestinal regulation, and has been approved by the Consumer Affairs Agency as a food ingredient with functional claims (improving bowel movement). .

It is important to create an intestinal environment where β-NMN is produced.

Originally, β-NMN is produced by intestinal bacteria together with B1, B2, B3, B5, B6, B7, B9, B12, K2 and folic acid.

The estimated amount of vitamin production produced by Bifidobacterium in the intestines of adults is considered to be 14-38% of the required amount, a proportion that cannot be ignored.

If you think about it naturally, no matter how much NMN you ingest, it is because other vitamins such as B1, B2, B3, B5, B6, B7, B9, B12, folic acid, and K2 are produced in a well-balanced manner. Regeneration continues.

Because it is produced in your own intestines, the vitamins are well-balanced, absorption is smooth, and subsequent metabolism works smoothly.

Cells work together to release various transmitters and carry out metabolism.

kinds	function
Thiamine (vitamin B1)	Helps break down carbohydrates Stabilizes the mind and supports growth
Riboflavin (vitamin B2)	Helps with cell regeneration and energy metabolism Creates healthy skin, hair, and nails
Niacin (vitamin B3)	Important for carbohydrate, lipid, and protein metabolism
Pantothenic acid (vitamin B5)	Helps metabolism of lipids, carbohydrates, and proteins Works on immunity along with vitamin B6 and folic acid
Pyridoxine (vitamin B6)	Creates healthy skin Involved in the synthesis of neurotransmitters
Cobalamin (vitamin B12)	Helps synthesize and repair nucleic acids and proteins in nerve cells Prevents pernicious anemia
Biotin (vitamin B7)	Helps hair and skin health Also associated with fatigue and depression
Folic acid (vitamin B9)	Important for anemia prevention Helps protein and nucleic acid synthesis
Menaquinone (Vitamin K2)	Related to blood coagulation Also important for bone metabolism

Step 2

Polymethoxyflavone derived from black ginger

Creates healthy fat cells with good metabolism.

Obtained patents for lipolysis (patent no. 5863721), muscle disease prevention, treatment, and muscle function improvement (patent no. 5903191, patent no. 5931309)

This ingredient has been approved by the Consumer Affairs Agency as a food ingredient with functional claims.

Reduces abdominal fat for those with a high BMI.
Makes it easier to consume fat during energy metabolism during daily activities.
Maintaining the walking ability of middle-aged and elderly people.

It is important to be able to convert absorbed β-NMN into NAD+ (nicotinamide adenine dinucleotide).

It is said that after the age of 50, NAD+ decreases to half of its peak level when young, accelerating aging.

As the amount of NAD+ increases, sirtuin genes become activated. The strengthened sirtuin genes actively protect mitochondria and telomeres, increasing skeletal muscle mass.

Absorbed β-NMN is converted to NAD+, which decreases with aging.

When NAD+ is synthesized in the hypothalamus of the brain, the sirtuin gene SIRT1 is activated, leading to improvements in physical activity ability and sleep quality. Also, when NAD+ is synthesized in the hippocampus of the brain, it leads to improved memory and learning ability. When NAD+ is synthesized in the retina, it leads to improved optic nerve cell function. The improvement of these three effects is expected to have a synergistic effect when taken together with our supplement Milagro AG.

Types of NMN

There are two types of NMN: α-NMN and β-NMN. Safe NMN is β-NMN, which is the same that is produced in the human body. The other is α-NMN, and its safety is unknown. There are many cheap NMN mixed with α-NMN on the market.

NMN ZERO REAL uses 100% β-NMN.

Manufacturing method of NMN

1. Synthesis method: using catalyst

Contains ingredients that are not permitted to be used in Japan under the Food Sanitation Act. Synthetic methods generally tend to leave behind impurities, and many products use ingredients that are not permitted under Japan's Food Sanitation Law. (Used in cosmetics, etc.)

2. Enzyme method: using enzymes

Materials from China undergo final processing using enzyme methods (using chemicals) at a Japanese factory, making them domestically produced. Since it is not a pure fermentation method, impurities tend to remain and there is no guarantee of safety.

3. Fermentation method: Fermentation with yeast

The reason why we insist on using yeast fermentation to produce NMN is because it is extremely similar to β-NMN produced in the intestines. NMN ZERO REAL is made using 100% yeast fermentation method.

Express the safety of ingredients in a way that anyone can understand.

NMN ZERO REAL requests an external organization to inspect the quality of its products so that safety can be confirmed at a glance.

Proof of security, safety, and trust

NMN ZERO REAL is a supplement that has received Informed Sports certification (WADA World Anti-Doping Regulations Certification) with the highest priority on safety and security.

Informed sports acquisition

This is an international anti-doping certification program run by LGC in the UK.
This is a program that strictly analyzes, inspects, and tests products to confirm that they do not contain prohibited substances based on the international standards for anti-doping regulations established by the World Anti-Doping Agency (WADA).

Like Informed Choice, Informed Sports is an anti-doping certification program operated by the UK-based Laboratory of Government Chemist (LGC) since 2008. LGC has over 50 years of research and experience in doping and has published over 300 scientific papers. Products are analyzed based on WADA's Prohibited List international standards, and major supplement brands from around the world have obtained certification.

Informed Sports Certification not only analyzes supplements, but also analyzes substances on WADA's list of prohibited substances, as well as substances deemed necessary by LGC based on the latest information at the time.

The only difference between Informed Sports and Informed Choice is the frequency of product analysis after certification. In addition to the same high-level product analysis performed in ISO17025-certified facilities and manufacturing process audits specific to anti-doping certification, Informed Choice offers monthly random sample analysis performed by a third party. Analyze and ensure safety and security.

Informed Sports, on the other hand, analyzes all manufacturing batches (full lot analysis). All lots of products that have been given Informed Sports certification have been analyzed, so athletes can use the products at any time with greater peace of mind without having to check the analysis results one by one. The introduction of this feature began in July 2020 for Japanese products.

Informed Sports Certificate

Traceability system

We want to deliver safety and security to everyone involved with NMN ZERO REAL.

With safety and security as our motto, we trace every step of the manufacturing management, storage management, and delivery management process, from manufacturing to the delivery of the product, and record and store all data in an effort to manage the safety and security of our products.

At Rejuvenation Systems, we strictly control the manufacturing, shipping, warehousing, and shipping of NMN ZERO REAL to dealers to ensure product reliability and safety. With the motto of safety and security, we trace every step of the manufacturing management, storage management, and delivery management process, from manufacturing to the delivery of the product, and record and store all data in an effort to manage the safety and security of our products. .

If you take a photo of the QR code on the side of the product using your smartphone's camera mode, the yellow button in the photo (cert.reju.jp) will appear. When you press this yellow button, the certificate will be displayed. You will usually see a blue Certificate of Authenticity. If a red "counterfeit" sign appears on the product, it is not an officially manufactured product and is a fraudulent product. Copy products of Milagro AG have been sold several times in the past. If you see a fake product, please check the store where you purchased it and contact the police.

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